反应详情

To 50 ml of dried pyridine, were added 5.1 g of 4-benzyloxycarbonylaminomethylbenzoic acid and 4.4 g of DCC. The mixture was stirred under cooling in ice for 30 minutes, admixed with 5.0 g of 6-amidino-2-naphthol methanesulfonate and stirred for one hour under cooling in ice, then overnight at room temperature. The reaction mixture was filtered* and the filtrate was mixed with ethyl ether. The precipitate which was formed was collected by filtration and recrystallized from a DMF-ethanol mixture to obtain 3.8 g of a white powder of a white powder of 6-amidino-2-naphthyl 4-benzyloxycarbonylaminomethylbenzoate methanesulfonate.

1. temperatureunder cooling in ice for 30 minutes
2. stirringstirred for one hour
3. temperatureunder cooling in ice
4. customovernight
5. customat room temperature
6. customThe precipitate which was formed
7. filtrationwas collected by filtration
8. customrecrystallized from a DMF-ethanol mixture