Water → HCID 178488735, compound

HRID 37144Notes

Reaction equation

HRID 37144 reaction equation
[N+](C1C=CC=CC=1)([O-])=O.[OH:10][C:11]1[N:16]2[N:17]=[CH:18][C:19]([C:20]3[CH:25]=[CH:24][C:23]([S:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:22][CH:21]=3)=[C:15]2[N:14]=[CH:13][C:12]=1[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=1.[Br:41]Br.O>CCOCC>[Br:41][C:37]1[CH:38]=[C:33]([C:12]2[CH:13]=[N:14][C:15]3[N:16]([N:17]=[CH:18][C:19]=3[C:20]3[CH:21]=[CH:22][C:23]([S:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:24][CH:25]=3)[C:11]=2[OH:10])[CH:34]=[CH:35][C:36]=1[O:39][CH3:40]

Participants

6

Reactant 4

HCID 962WaterHCID 7416NitrobenzeneHCID 24408BromineHCID 178488734HCID 178488734, compound

Product 1

HCID 178488735HCID 178488735, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a 2-ml nitrobenzene suspension of 420 mg of 7-hydroxy-6-(4-methoxyphenyl)-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine, 0.1 ml of bromine was added and stirred for 1 hour at room temperature, and water and ether were added, and the precipitate was filtered. It was washed with water, methanol, ethyl acetate and ether, dried, and the title compound was obtained (270 mg, 54%).

Workup

  1. additionwas added
  2. filtrationthe precipitate was filtered
  3. washIt was washed with water, methanol, ethyl acetate and ether
  4. customdried

Sources & evidence

ORD record
ord-77d059eca5614bcd81529d2aff039c50
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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