Tetrabutylammonium Fluoride → HCID 13216467, compound

Participants

Reaction Steps

A solution of 900 mg of the furan derivative produced in Example 12 in 120 ml of absolute tetrahydrofuran is combined with 960 mg of tetrabutylammonium fluoride dissolved in 10 ml of tetrahydrofuran, and the mixture is stirred under argon at room temperature for 1 hour. Thereafter the reaction solution is precipitated into ice water, and the aqueous phase is extracted repeatedly with ether. The organic phases are combined, washed with water and then with semisaturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The crude product is chromatographed over 60 g of silica gel in a hexane/20% acetone-hexane gradient, thus obtaining 648 mg of the title compound as an oil.

Provenance & Evidence