Ethanol → HCID 13478351, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.0 g (2.96 mmole) of 5-[4-(4-cyanophenyl)-1-piperazinyl]-6-propyl-2,4-pyrimidinediamine, 15 ml of 95% ethanol and 15 ml of sulfuric acid was heated under reflux at 100° C. for four hours and cooled. The solution was poured into 200 ml of ice water and filtered. The filtrate was kept cool and neutralized with 50% aqueous sodium hydroxide solution to pH 7. The solid was collected and washed with 50 ml of water. Recrystallization from N,N-dimethylformamide and drying in vacuo at 78° C. for 16 hours gave 0.7 g of the product as a white solid, mp 215°-216° C.

Provenance & Evidence