Diethylcarbamoyl chloride → 1-Diethylcarbamoyl-3-propylthio-1,2,4-triazole

Participants

Reaction Steps

A mixture of 7.2 g. 3-propylthio-1,2,4-triazole, 6.8 g. diethylcarbamoyl chloride, 35 ml. dry tetrahydrofuran and 9 ml. dry triethylamine was refluxed under anhydrous conditions for 72 hours. The reaction mixture was worked up as described in Example 1 to produce a residual oil. This oil was distilled under reduced pressure to give 1-diethylcarbamoyl-3-propylthio-1,2,4-triazole, b.p. 118° - 121° C./0.2 mm. (89.9% 1-isomer by GLC assay). Elemental analysis satisfactory.

Provenance & Evidence