Potassium Hydroxide → HCID 20355352, compound

HRID 371628Notes

Reaction equation

HRID 371628 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8](=[S:15])[NH:7][C:6]=2[CH:16]=1.[OH-].[K+].S([O-])(O[CH3:23])(=O)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8]([S:15][CH3:23])=[N:7][C:6]=2[CH:16]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 4694097Methyl sulfate(1-)HCID 20355329HCID 20355329, compound

Product 1

HCID 20355352HCID 20355352, compound

Procedure

In a similar manner 7-fluoro-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-thione is reacted with potassium hydroxide and methyl sulfate to give 7-fluoro-10-(Methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine.

Sources & evidence

ORD record
ord-f893eb019e5b4434973494af43ee2b72
Source dataset
uspto-grants-1978_05
Patent number
US04087421

Reaction notes

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