Piperidine → HCID 20355332, compound

Participants

Reaction Steps

A solution of 0.7 g. of 10-(methylthio)-4H-thieno[3,4-b][1,5]benzodiazepine in 5 ml. of piperidine is treated with a drop of glacial acetic acid and heated under reflux for 4 days. Excess piperidine is removed under reduced pressure and the oily residue is warmed with dilute acetic acid and filtered. The filtrate is cooled and made alkaline with concentrated ammonium hydroxide to give a yellow solid. Recrystallization from acetone-petroleum ether (30°-60° C.) gives yellow crystals, m.p. 157°-159° C.

Provenance & Evidence