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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37165Generated: October 25, 2026

1-(Bis(4-fluorophenyl)methyl)piperazine → 7-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin

https://huagongshe.com/reaction/37165

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bis(4-fluorophenyl)methyl)piperazineHCID 152932—
Reactant7-Hydroxy-1,4-benzodioxin-2-carboxylic acidHCID 10932311—
Product7-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxinHCID 1099423176%

Reaction Steps

That compound is obtained in a yield of 76% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 7-hydroxy-1,4-benzodioxin-2-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05420132
Source datasetuspto-grants-1995_05
ORD IDord-05756995591643b6972f82f5acd7bf95
Source noteuspto-grants-1995_05