Diethyl Ether → HCID 20355554, compound

Participants

Reaction Steps

A solution of thiolacetic acid (10.0 g., 0.13 mole) and 4-benzyloxy-3-acetoxy-1-butene (21.0 g., 0.096 mole) containing benzoxyl peroxide (50 mg.) is stirred at room temperature for 20 hours. The reaction mixture is taken up in ether (200 ml.), washed with saturated sodium bicarbonate solution until neutral and then with brine and dried over sodium sulfate. The ether is removed in vacuo and the resulting oil is purified by chromatography over silica gel using hexane-ethyl acetate (80-20) to elute. From the proper fraction there is obtained 18.0 g. (64%) of the title compound as a heavy oil.

Provenance & Evidence