N-(5-Chloro-3-nitropyridin-2-yl)-2,2,2-trifluoroacetamide → 1-Hydroxyfluromidine

Participants

Reaction Steps

5-Chloro-3-nitro-2-(trifluoroacetamido)pyridine (2.0 grams) was hydrogenated with two moles of hydrogen in ethanol containing 0.5 gram of 5 percent palladium on carbon. The resulting reaction mixture was filtered and evaporated to separate the desired 6-chloro-1-hydroxy-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine compound which, after recrystallization from benzene melted at 268°-70° C.

Provenance & Evidence