Sodium Fluoride → HCID 20355493, compound

HRID 371668Notes

Reaction equation

HRID 371668 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]=[C:9]([CH:12]([F:14])[F:13])[N:10]([OH:11])[C:3]=12.[F-:15].[Na+]>>[F:15][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]=[C:9]([CH:12]([F:14])[F:13])[N:10]([OH:11])[C:3]=12

Participants

3

Reactant 2

HCID 5235Sodium FluorideHCID 20355528HCID 20355528, compound

Product 1

HCID 20355493HCID 20355493, compound

Procedure

7-Chloro-1-hydroxy-2-(difluoromethyl)-1H-imidazo(4,5-b)pyridine is reacted with sodium fluoride to obtain 7-fluoro-1-hydroxy-2-(difluoromethyl)-1H-imidazo(4,5-b)pyridine, which is then converted to its calcium salt.

Sources & evidence

ORD record
ord-e5f72abeff8148b793a3dfd22b138ade
Source dataset
uspto-grants-1978_05
Patent number
US04087432

Reaction notes

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