HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5,6-Dichloro-2-(2,2,3,3-tetrafluoropropionamido)-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-5-chloro-3-nitropyridine | HCID 224168 | — |
| Reactant | 2,2,3,3-Tetrafluoropropanoyl chloride | HCID 2776744 | — |
| Reactant | 5,6-Dichloro-3-nitropyridin-2-amine | HCID 15392047 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5,6-Dichloro-3-nitropyridin-2-amine | HCID 15392047 | — |
| Product | 5,6-Dichloro-2-(2,2,3,3-tetrafluoropropionamido)-3-nitropyridine | HCID 20355486 | 94% |
Reaction Steps
5,6-Dichloro-2-amino-3-nitropyridine was prepared by chlorination of 5-chloro-2-amino-3-nitropyridine and was subsequently reacted with 2,2,3,3-tetrafluoropropionyl chloride. More particularly, 5,6-dichloro-2-amino-3-nitropyridine (3.0 grams; 0.15 mole) was taken up in tetrahydrofuran (20 ml.) and triethylamine (2 ml.) was added. Then 2,2,3,3-tetrafluoropropionyl chloride was added portionwise until all the starting material had reacted. The reaction yielded 5.3 grams (94 percent yield) of 5,6-dichloro-2-(2,2,3,3-tetrafluoropropionamido)-3-nitropyridine as an oil. Its identity was confirmed by infrared spectroscopy.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04087432 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-b73a1749fe3d4ae39de37129aa3e7e93 |
| Source note | uspto-grants-1978_05 |