HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → Indole-3-Carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Product | Indole-3-Carboxaldehyde | HCID 10256 | — |
Reaction Steps
As shown by the above generalized scheme, the indole is treated with phosphorus oxychloride and DMF to produce the corresponding 3-formyl indole (XIV). The latter is treated with nitromethane and ammonium acetate to obtain the corresponding 3-(2'-nitroethenyl)indole (XV), which then is reduced to the desired tryptamine (XVI).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04087444 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-132f02bc76474e77bae2d8221eba4292 |
| Source note | uspto-grants-1978_05 |