反应详情

Cyclohexyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide (0.045 mole) was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid and the solid recrystallized from an appropriate solvent such as methanol. m.p. 180°-3° C.; yield 57%.

1. stirringThe solution was stirred overnight
2. filtrationthe mixture filtered
3. concentrationThe filtrate was concentrated to a solid
4. customthe solid recrystallized from an appropriate solvent such as methanol