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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37170Generated: October 26, 2026

1-(Bis(4-fluorophenyl)methyl)piperazine → 6-Hydroxy-7-tert-butyl-2-{4-[bis-(4-fluorophenyl) methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxin

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Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bis(4-fluorophenyl)methyl)piperazineHCID 152932—
Reactant6-Hydroxy-7-tert-butyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acidHCID 19392495—
Product6-Hydroxy-7-tert-butyl-2-{4-[bis-(4-fluorophenyl) methyl]piperazin-1-ylcarbonyl}-2,3-dihydro-1,4-benzodioxinHCID 1939243674%

Reaction Steps

That compound is obtained in a yield of 74% starting from 1-[bis(4-fluorophenyl) methyl]piperazine and 6-hydroxy-7-tert-butyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05420132
Source datasetuspto-grants-1995_05
ORD IDord-532f46387a1c4e28b58d148e451f20e8
Source noteuspto-grants-1995_05