Thionyl Chloride → HCID 20355929, compound

HRID 371715Notes

Reaction equation

HRID 371715 reaction equation
O[CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5].S(Cl)([Cl:14])=O>>[Cl:14][CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([Cl:7])([Cl:6])[CH2:4][Cl:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 3026119N-(2,2,3-Trichloro-1-hydroxypropyl)acetamide

Product 1

HCID 20355929HCID 20355929, compound

Procedure

30 ml of thionyl chloride were poured over 15 gm of N-(1-hydroxy-2,2,3-trichloro-n-propyl)-acetamide, and the mixture was refluxed until the solution became clear. Subsequently, the excess thionyl chloride was distilled off in vacuo, and the residue was recrystallized from benzene/petroleum ether. Upon washing of the crystallizate with petroleum ether, a colorless substance was obtained. Yield: 13.5 gm; m.p. 70°-72° C.

Workup

  1. temperaturethe mixture was refluxed until the solution
  2. distillationSubsequently, the excess thionyl chloride was distilled off in vacuo
  3. customthe residue was recrystallized from benzene/petroleum ether
  4. washUpon washing of the crystallizate with petroleum ether
  5. customa colorless substance was obtained

Sources & evidence

ORD record
ord-2348e1ba22d6466781408a36d07d89e0
Source dataset
uspto-grants-1978_05
Patent number
US04087533

Reaction notes

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