Diazomethane → HCID 20356176, compound

HRID 371742Notes

Reaction equation

HRID 371742 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[N:12]2[CH2:13][CH2:14][CH:15]([C:16]([OH:18])=[O:17])[C:11]2=[CH:10][CH:9]=1)=[O:7].[N+](=[CH2:21])=[N-]>ClCCl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[N:12]2[CH2:13][CH2:14][CH:15]([C:16]([O:18][CH3:21])=[O:17])[C:11]2=[CH:10][CH:9]=1)=[O:7]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 203560965-(Furan-2-carbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Product 1

HCID 20356176HCID 20356176, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 200 mg. of 5-(2-furoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of dichloromethane is treated with an excess of ethereal diazomethane, and the reaction mixture is maintained at room temperature for 30 minutes. The solvents and excess reagent are eliminated under reduced pressure and the residue crystallized from ethyl acetate-methanol, to yield methyl 5-(2-furoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.

Workup

  1. customthe residue crystallized from ethyl acetate-methanol

Sources & evidence

ORD record
ord-2839e573a54141379294f4875d5834c4
Source dataset
uspto-grants-1978_05
Patent number
US04087539

Reaction notes

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