1,2-Dichloroethane → HCID 20356415, compound

Participants

Reaction Steps

A portion (5.98g) of this material, 4-methyl-2-pentanone p-ethoxyphenylimine, combined with iodine (0.15g), ethylene dichloride (0.5 ml) and acetone (200 ml), was refluxed for about 26 hours in a Soxhlet extractor, which was charged with molecular sieves 3A and fitted with a moisture trap at the condenser outlet. The product was evaporated to dryness in vacuo and then fractionated. Fractions with b.p.≥120° C/0.5 mm were combined and the brown oil (3.26lg) was chromatographed on silica gel (180g, mesh 70-230). Benzene (2 l.) and benzene-chloroform (9:1, 1.5 l.) eluates furnished 1,2-dihydro-2,4-dimethyl-2-isobutyl-6-ethoxyquinoline as a brown oil (1.88g).

Provenance & Evidence