HCID 12534478, compound → HCID 12534479, compound

HRID 371771Notes

Reaction equation

HRID 371771 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][C:5]1=[O:15].[H][H]>[Pd].C(O)C>[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH:7]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:6][C:5]1=[O:15]

Participants

5

Reactant 2

HCID 12534478HCID 12534478, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12534479HCID 12534479, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A slurry of 1-(2-hydroxyethyl)-4-phenyl-4-imidazolin-2-one (10.2 g.) and 10 percent palladium on carbon (1 g.) in ethanol (200 ml.) is hydrogenated in a Parr Shaker apparatus at approximately 30 psig of hydrogen for three hours. The catalyst is then filtered, washed with ethanol, and the combined filtrate and washings are concentrated to give a colorless oil which solidifies on standing to yield the title compound; m.p. 60°-63° C.

Workup

  1. filtrationThe catalyst is then filtered
  2. washwashed with ethanol
  3. concentrationthe combined filtrate and washings are concentrated
  4. customto give a colorless oil which

Sources & evidence

ORD record
ord-b13699b02c664728b6da3bfd2029a5e9
Source dataset
uspto-grants-1978_05
Patent number
US04087611

Reaction notes

Loading…