HRID37181

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID82604

Nicotinoyl chloride

C6H4ClNO

结构：O=C(C1=COc2ccc(O)cc2O1)N1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1

HCID10994231

未命名化合物

PRODUCTS

生成物

结构：O=C(Oc1ccc2c(c1)OC(C(=O)N1CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC1)=CO2)c1cccnc1

HCID19392473

未命名化合物

收率 78%

PROCEDURE

实验过程

That compound is obtained in a yield of 78% starting from 7-hydroxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin and nicotinoyl chloride by proceeding as for Example 53. ##STR76##

WORKUP

后处理

customThat compound is obtained in a yield of 78%

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ed0f98eaa21458699b45544e350a72d
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05420132
来源说明: uspto-grants-1995_05

反应 SMILES

[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH:9]=[C:8]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH:19]([C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=4)[C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=4)[CH2:15][CH2:14]3)=[O:12])[O:7][C:6]=2[CH:34]=1.[C:35](Cl)(=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[N:38][CH:37]=1>>[C:35]([O:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH:9]=[C:8]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH:19]([C:27]4[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=4)[C:20]4[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=4)[CH2:15][CH2:14]3)=[O:12])[O:7][C:6]=2[CH:34]=1)(=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[N:38][CH:37]=1