HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetamide, 2-(trimethylsilyl)- → 3beta,17beta,19-Tri(trimethylsiloxy)androst-4-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetamide, 2-(trimethylsilyl)- | HCID 357676 | — |
| Reactant | 4-Androstene-3beta,17beta,19-triol | HCID 70584792 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3beta,17beta,19-Tri(trimethylsiloxy)androst-4-ene | HCID 22803268 | — |
Reaction Steps
Androst-4-ene-3β,17β,19-triol is dissolved in dry pyridine and trimethylsilylacetamide added thereto. The reaction is completed at room temperature within a few minutes. The pyridine is removed under reduced pressure and the residue purified from an acetone-hexane solution to yield the desired 3β,17β,19-tri(trimethylsiloxy)androst-4-ene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04087524 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-dbc2d24b0ed64bcba579f15a7133855b |
| Source note | uspto-grants-1978_05 |