HCID 22797467, compound → HCID 22803266, compound

HRID 371822Notes

Reaction equation

HRID 371822 reaction equation
[C:1](OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](O)CC4)CCC1=C[C@@H](O)C[C@H]2C)(=O)C.[C:27](OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](O)CC4)C[C@H](C)C1=C[C@@H](O)CC2)(=O)C.[C:53]([O:56][CH2:57][C@@:58]12[C@@H:75]3[C@H:66]([C@H:67]4[C@@:71]([CH2:73][CH2:74]3)([CH3:72])[C@@H:70]([O:76][Si:77]([C:90]3[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=3)([C:84]3[CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=3)[C:78]3[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=3)[CH2:69][CH2:68]4)[CH2:65][CH2:64][C:63]1=[CH:62][C@@H:61]([O:96][Si:97]([C:110]1[CH:115]=[CH:114][CH:113]=[CH:112][CH:111]=1)([C:104]1[CH:109]=[CH:108][CH:107]=[CH:106][CH:105]=1)[C:98]1[CH:103]=[CH:102][CH:101]=[CH:100][CH:99]=1)[CH2:60][CH2:59]2)(=[O:55])[CH3:54]>>[C:53]([O:56][CH2:57][C@@:58]12[C@@H:75]3[C@H:66]([C@H:67]4[C@@:71]([CH2:73][CH2:74]3)([CH3:72])[C@@H:70]([O:76][Si:77]([C:90]3[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=3)([C:84]3[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=3)[C:78]3[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=3)[CH2:69][CH2:68]4)[CH2:65][CH2:64][C:63]1=[CH:62][C@@H:61]([O:96][Si:97]([C:104]1[CH:105]=[CH:106][CH:107]=[CH:108][CH:109]=1)([C:98]1[CH:99]=[CH:100][CH:101]=[CH:102][CH:103]=1)[C:110]1[CH:115]=[CH:114][CH:113]=[CH:112][CH:111]=1)[CH2:60][C@H:59]2[CH3:1])(=[O:55])[CH3:54].[C:53]([O:56][CH2:57][C@@:58]12[C@@H:75]3[C@H:66]([C@H:67]4[C@@:71]([CH2:73][CH2:74]3)([CH3:72])[C@@H:70]([O:76][Si:77]([C:90]3[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=3)([C:84]3[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=3)[C:78]3[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=3)[CH2:69][CH2:68]4)[CH2:65][C@H:64]([CH3:27])[C:63]1=[CH:62][C@@H:61]([O:96][Si:97]([C:104]1[CH:105]=[CH:106][CH:107]=[CH:108][CH:109]=1)([C:98]1[CH:99]=[CH:100][CH:101]=[CH:102][CH:103]=1)[C:110]1[CH:115]=[CH:114][CH:113]=[CH:112][CH:111]=1)[CH2:60][CH2:59]2)(=[O:55])[CH3:54]

Participants

5

Reactant 3

HCID 22797467HCID 22797467, compoundHCID 70585938HCID 70585938, compoundHCID 70585976HCID 70585976, compound

Product 2

HCID 22803266HCID 22803266, compoundHCID 22803274HCID 22803274, compound

Procedure

Substituting 1β-methyl-4-androstene-3β,17β,19-triol 19-acetate and 6α-methyl-4-androstene-3β,17β,19-triol 19-acetate for the androst-4-ene-3β,17β,19-triol 19-acetate above, results in the preparation of 1β-methyl-3β,17β-di-(triphenylsiloxy)-4-androsten-19-ol acetate and 6α-methyl-3β,17β-di-(triphenylsiloxy)-4-androsten-19-ol acetate.

Sources & evidence

ORD record
ord-c8876082819945a1b70fc2c5433da8f0
Source dataset
uspto-grants-1978_05
Patent number
US04087524

Reaction notes

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