HCID 86735687, compound → HCID 22803253, compound

HRID 371825Notes

Reaction equation

HRID 371825 reaction equation
[C:1](O)(=O)C.[OH:5][CH2:6][C@@:7]12[C@@H:24]3[C@H:15]([C@H:16]4[C@@:20]([CH2:22][CH2:23]3)([CH3:21])[C@@H:19]([O:25][C:26]3([O:32][CH3:33])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH2:18][CH2:17]4)[CH2:14][C@H:13]([CH3:34])[C:12]1=[CH:11][C:10](=[O:35])[CH2:9][CH2:8]2.C(O)(=O)C.OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](OC3(OC)CCCCC3)CC4)CCC1=CC(=O)CC2>>[OH:5][CH2:6][C@@:7]12[C@@H:24]3[C@H:15]([C@H:16]4[C@@:20]([CH2:22][CH2:23]3)([CH3:21])[C@@H:19]([O:25][C:26]3([O:32][CH3:33])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH2:18][CH2:17]4)[CH2:14][CH2:13][C:12]1=[CH:11][C:10](=[O:35])[CH2:9][C@H:8]2[CH3:1].[OH:5][CH2:6][C@@:7]12[C@@H:24]3[C@H:15]([C@H:16]4[C@@:20]([CH2:22][CH2:23]3)([CH3:21])[C@@H:19]([O:25][C:26]3([O:32][CH3:33])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[CH2:18][CH2:17]4)[CH2:14][C@H:13]([CH3:34])[C:12]1=[CH:11][C:10](=[O:35])[CH2:9][CH2:8]2

Participants

4

Reactant 2

HCID 86735687HCID 86735687, compoundHCID 86735688HCID 86735688, compound

Product 2

HCID 22803253HCID 22803253, compoundHCID 22803255HCID 22803255, compound

Procedure

Following essentially the same procedure and substituting 19-hydroxy-17β-(1'-methoxycyclohexyloxy)-β-methylandrost-4-en-3-one acetate and 19-hydroxy-17β-(1'-methoxycyclohexyloxy)-6α-methylandrost-4-en-3-one acetate for the 19-hydroxy-17β-(1'-methoxycyclohexyloxy)androst-4-en-3-one acetate above, results in the preparation of 19-hydroxy-17β-(1'-methoxycyclohexyloxy)-1β-methylandrost-4-en-3-one and 19-hydroxy-17β-(1'-methoxycyclohexyloxy)-6α-methylandrost-4-en-3-one, respectively.

Sources & evidence

ORD record
ord-7bbad1fd8a034478bfb38fd32d65e178
Source dataset
uspto-grants-1978_05
Patent number
US04087524

Reaction notes

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