反应详情

To a solution of potassium t-butoxide in dimethyl-sulfoxide at 25° C. under nitrogen is added 1,4-androstadiene-3,17-dione in dimethylsulfoxide with stirring. After fifteen minutes the mixture is poured onto cold aqueous ammonium chloride. The solid is rapidly filtered, washed well with water and dissolved in ether. The ether solution is washed again with water, dried over sodium sulfate and evaporated at room temperature to yield 1,5-androstadiene-3,17-dione.

1. filtrationThe solid is rapidly filtered
2. washwashed well with water
3. dissolutiondissolved in ether
4. washThe ether solution is washed again with water
5. dry with materialdried over sodium sulfate
6. customevaporated at room temperature