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HRID371846

反应详情

EQUATION

反应方程式

HRID 371846 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)[C@H]5C[C@H]5[C@@]43C)[C@@H]1CC[C@@H]2O
HCID56628685

未命名化合物

结构：CC(C)=O.O=S(=O)(O)O.[O]=[Cr](=[O])=[O]
HCID131709961

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@]12C(=CC(=O)[C@H]3C[C@H]31)CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID54262378

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

The 1β,2β-methylene-5-androstene-3β,17β-diol is dissolved in acetone and Jones reagent added until a persistent yellow-orange color appears. After stirring at room temperature for ten minutes the mixture is poured onto ice-water and the precipitate is collected by filtration. The precipitate is dissolved in a solution of sodium methoxide in methanol and stirred for a period of 30 minutes at room temperature. The methanol is removed and the residue triturated with water. The solid which results is filtered and crystallized from acetone to yield 1β,2β-methylene-4-androstene-3,17-dione.

WORKUP

后处理

  1. additionis poured onto ice-water
  2. filtrationthe precipitate is collected by filtration
  3. dissolutionThe precipitate is dissolved in a solution of sodium methoxide in methanol
  4. stirringstirred for a period of 30 minutes at room temperature
  5. customThe methanol is removed
  6. customthe residue triturated with water
  7. customThe solid which results
  8. filtrationis filtered
  9. customcrystallized from acetone