HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1beta-Methyl-4-androstene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1beta,2beta-Methylene-4-androstene-3,17-dione | HCID 54262378 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1beta-Methyl-4-androstene-3,17-dione | HCID 54175784 | — |
Reaction Steps
1β,2β-Methylene-4-androstene-3,17-dione, zinc powder, and acetic acid are refluxed together for a period of 1 hour. On cooling benzene is added, the suspension filtered and the filtrate taken to dryness under vacuum. The residue is chromatographed on silica gel and eluted with methylenechloride. Recrystallization from acetone-hexane yields 1β-methyl-4-androstene-3,17-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04087524 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-f9f0e164010b422faa5463e3619c012f |
| Source note | uspto-grants-1978_05 |