反应详情

To a solution of potassium t-butoxide in dimethylsulfoxide at 25° C. under nitrogen is added 1β-methyl-4-androstene-3,17-dione in dimethylsulfoxide with stirring. After 15 minutes the mixture is poured onto cold aqueous ammonium chloride. The solid is rapidly filtered, washed well with water and dissolved in ether. The ether is washed with water, dried over sodium sulfate and removed at room temperature to yield 1β-methyl-5-androstene-3,17-dione.

1. filtrationThe solid is rapidly filtered
2. washwashed well with water
3. dissolutiondissolved in ether
4. washThe ether is washed with water
5. dry with materialdried over sodium sulfate
6. customremoved at room temperature