7alpha-Methyl-4-androstene-3beta,17beta,19-triol → 17beta,19-Dihydroxy-7alpha-methyl-4-androstene-3-one

Participants

Reaction Conditions

Reaction Steps

7α-Methyl-4-androstene-3β,17β,19-triol is dissolved in hot chloroform and cooled to 15° C. Activated manganese dioxide is added at a rate such that the temperature does not rise above 25° C. Stirring is continued at room temperature for about 1 hour, the manganese dioxide is removed by filtration through a bed of diatomaceous earth and the chloroform distilled under vacuum. The residue which remains is crystallized from acetonitrile to yield 17β,19-dihydroxy-7α-methyl-4-androsten-3-one.

Provenance & Evidence