Ethanol → HCID 20318972, compound

HRID 371869Notes

Reaction equation

HRID 371869 reaction equation
[NH:1]([C:5]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:6]=1[CH2:7][N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])C(C)=O.[OH-].[Na+].C([OH:23])C>O>[NH2:1][C:5]1[CH:16]=[CH:15][C:14]([C:17](=[O:23])[NH2:18])=[CH:13][C:6]=1[CH2:7][N:8]([CH2:11][CH3:12])[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 20319034HCID 20319034, compound

Product 1

HCID 20318972HCID 20318972, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 10 gm of 2-acetamino-5-cyano-N,N-diethyl-benzylamine, 100 ml of 5 N sodium hydroxide and 70 ml of ethanol was boiled for 4 hours. Thereafter, the reaction solution was cooled, diluted with 200 ml of water and extracted three times with 250 ml of chloroform each. The combined chloroform extracts were dried over sodium sulfate and evaporated in vacuo, and the residue was recrystallized from ethanol. The 2-amino-5-carbamoyl-N,N-diethyl-benzylamine of m.p. 129-131° C was obtained.

Workup

  1. temperatureThereafter, the reaction solution was cooled
  2. extractionextracted three times with 250 ml of chloroform each
  3. dry with materialThe combined chloroform extracts were dried over sodium sulfate
  4. customevaporated in vacuo
  5. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-040568604a0148359c618d8534e311a1
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

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