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Water → 2-[p-(2,4-Dichlorobenzyl)-phenoxi]-propionic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromopropanamide | HCID 101118 | — |
| 反応物 | 4-(2,4-Dichlorobenzyl)-phenol | HCID 13938709 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[p-(2,4-Dichlorobenzyl)-phenoxi]-propionic acid amide | HCID 70622740 | — |
反応手順
A solution of 25.3 g of 4-(2,4-dichlorobenzyl)-phenol and 15.2 g of α-bromopropionic acid amide in 100 ml of dimethyl formamide was stirred for 2 hours at 100° C together with 16 g of potassium carbonate. After cooling, the reaction mixture was poured into 1 liter of water. A viscous oil precipitated which was absorbed in methylene chloride and washed with water. After drying over sodium sulfate, the solvent was distilled off under reduced pressure. The remaining colorless crystals were recrystallized from methanol. Yield: 25.8 g; melting point 148° - 149° C. ##STR5##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04088474 |
| 出典データセット | uspto-grants-1978_05 |
| ORD ID | ord-5991b704c0034b9283fb1896623af89d |
| 出典メモ | uspto-grants-1978_05 |