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HRID 371890作成日:2026年10月25日

Water → 2-[p-(2,4-Dichlorobenzyl)-phenoxi]-propionic acid amide

https://huagongshe.com/reaction/371890

反応式

関与物質

役割名称HCID仕込み量
反応物WaterHCID 962—
反応物Potassium CarbonateHCID 11430—
反応物2-BromopropanamideHCID 101118—
反応物4-(2,4-Dichlorobenzyl)-phenolHCID 13938709—
溶媒DimethylformamideHCID 6228—
生成物2-[p-(2,4-Dichlorobenzyl)-phenoxi]-propionic acid amideHCID 70622740—

反応手順

A solution of 25.3 g of 4-(2,4-dichlorobenzyl)-phenol and 15.2 g of α-bromopropionic acid amide in 100 ml of dimethyl formamide was stirred for 2 hours at 100° C together with 16 g of potassium carbonate. After cooling, the reaction mixture was poured into 1 liter of water. A viscous oil precipitated which was absorbed in methylene chloride and washed with water. After drying over sodium sulfate, the solvent was distilled off under reduced pressure. The remaining colorless crystals were recrystallized from methanol. Yield: 25.8 g; melting point 148° - 149° C. ##STR5##

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US04088474
出典データセットuspto-grants-1978_05
ORD IDord-5991b704c0034b9283fb1896623af89d
出典メモuspto-grants-1978_05