反应详情

温度

80 °C

2.6 g of 5-fluorouracil was suspended in 20 ml of absolute dioxane and 10 ml of absolute pyridine, and 15 g of palmityl chloride was added to the suspension followed by heating at 80° C for 1 hour while stirring. After completion of the reaction, the solvent was removed under reduced pressure (25 mm Hg), and the residual solid was washed with hot hexane (50° C). Any insoluble matter in the hot hexane was recrystallized from benzene to obtain 4.0 g of 1-N-palmitoyl-5-fluorouracil in a yield of 54%. Melting Point: 98° C.

1. customAfter completion of the reaction
2. customthe solvent was removed under reduced pressure (25 mm Hg)
3. washthe residual solid was washed with hot hexane (50° C)
4. customAny insoluble matter in the hot hexane was recrystallized from benzene