HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 7-chloro-3,5-dimethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 5-Amino-6-methylamino-4-chloro-2-methylpyridine-3-carboxylic acid ethyl ester | HCID 12387617 | — |
| Product | 7-chloro-3,5-dimethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester | HCID 12387640 | — |
Reaction Steps
2.4 g. of 5-Amino-6-methylamino-4-chloro-2-methylpyridine-3-carboxylic acid ethyl ester (0.01 mol.) and 10 ml. of orthoformic acid triethyl ester are refluxed for 12 hours. After the excess ortho ester has been removed, the residue is recrystallized from ethyl acetate to obtain 7-chloro-3,5-dimethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester, m.p. 56°-58°. Yield 2.2 g. (88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04088654 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-8f0db467ef234e229b9b6f21ecf1c85f |
| Source note | uspto-grants-1978_05 |