HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester → 3-butyl-7-chloro-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester | HCID 12387618 | — |
| Reactant | 5-Amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester | HCID 12387619 | — |
| Product | 3-butyl-7-chloro-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester | HCID 12387639 | 83% |
Reaction Steps
By replacing 5-amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester in Example 1 d with 5-amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester, 3-butyl-7-chloro-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester is obtained. Yield 83%, b.p. 190°-200°/0.01.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04088654 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-e08218d3d8a743cdb6c3156e971aecb5 |
| Source note | uspto-grants-1978_05 |