Ciproximida → 1-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

HRID 371939Notes

Reaction equation

HRID 371939 reaction equation
[CH2:1]1[C:3]2([C:9]3[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=3)[C:4]([NH:6][C:7](=O)[CH:2]12)=O.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>C1C=CC=CC=1>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:3]23[CH2:1][CH:2]2[CH2:7][NH:6][CH2:4]3)=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 27361CiproximidaHCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydride

Product 1

HCID 101303311-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Following the procedure described in Example 1 the compound 1-(p-chlorophenyl)-1,2-cyclopropanedicarboximide (U.S. Pat. No. 3,344,026--Example 1) is reduced with sodium bis(2-methoxyethoxy)aluminum hydride 70% solution in benzene to produce the compound 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane.

Sources & evidence

ORD record
ord-40e8df6a7a24451c975d78e4c626b274
Source dataset
uspto-grants-1978_05
Patent number
US04088652

Reaction notes

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