4-Nitrobenzoyl chloride → HCID 20352248, compound

Participants

Reaction Steps

A 19.35 g. portion of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane is dissolved in 150 ml. of benzene. A 10.59 g. portion of sodium carbonate in 100 ml. of water is added with stirring. An 18.45 g. portion of p-nitrobenzoyl chloride in 100 ml. of benzene is added slowly to the rapidly stirred mixture. The mixtue is stirred for 1 hour and then allowed to stand overnight at room temperature. The product is recovered by filtration, washed successively with dilute sodium carbonate, 0.5N hydrochloric acid and then water and dried yielding the product as a white solid, mp 177°-180° C.

Provenance & Evidence