反应详情

Following the procedure of Example 8, 19.35 g. of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g. of sodium carbonate and 17.5 g. of p-chlorobenzoyl chloride are reacted. The benzene is evaporated and the dark purple residue is dissolved in 200 ml. of chloroform and washed successively with 5% sodium carbonate, 0.5N Hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. The oil is extracted with ether giving the product as grey crystals, mp 98°-100° C.

1. customThe benzene is evaporated
2. dissolutionthe dark purple residue is dissolved in 200 ml
3. washof chloroform and washed successively with 5% sodium carbonate, 0.5N Hydrochloric acid
4. dry with materialwith water and dried over sodium sulfate giving a dark purple oil
5. extractionThe oil is extracted with ether giving the product as grey crystals, mp 98°-100° C.