Sodium Carbonate → HCID 20352245, compound

HRID 371944Notes

Reaction equation

HRID 371944 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:13][CH:12]2[CH2:11][NH:10][CH2:9]3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([N:10]2[CH2:11][CH:12]3[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)([CH2:13]3)[CH2:9]2)=[O:26])=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 678794-Fluorobenzoyl chlorideHCID 101303311-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane

Product 1

HCID 20352245HCID 20352245, compound

Procedure

Following the procedure of Example 8, 19.35 g. of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g. of sodium carbonate and 15.8 g. of p-fluorobenzoyl chloride are reacted. Ether extraction of the reaction product gives a white solid, mp 130°-132° C.

Workup

  1. extractionEther extraction of the reaction product
  2. customgives a white solid, mp 130°-132° C.

Sources & evidence

ORD record
ord-1e8c3825b65c4a9b9ae7284e81635189
Source dataset
uspto-grants-1978_05
Patent number
US04088652

Reaction notes

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