HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Formyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-(4-Chlorophenyl)-3-azabicyclo[3.1.0]hexane | HCID 10130331 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 3-Formyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane | HCID 20352257 | — |
Reaction Steps
A solution of 1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane in formic acid is added at 0°-5° C. to aceticformic anhydride prepared from 2 volumes of acetic anhydride and one volume of formic acid. The mixture is warmed to 40°-50° C. and poured onto ice to give 3-formyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04088652 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-6bfb7084ab1c4724a23a0979875ac86c |
| Source note | uspto-grants-1978_05 |