Diethyl Ether → HCID 20352315, compound

Participants

Reaction Steps

A solution of 25 mM of the ester obtained according to letter (i) above in 13 ml of anhydrous ether was added under stirring to a solution of 0.66 (17.5 mM) of LiAlH4 in 35 ml of anhydrous ether. Stirring was carried on at room temperature for 22 h, whereupon the reaction mixture was poured onto ice. After acidification with a 10% aqueous HCl solution, extraction with ether, washing with water and drying, followed by evaporation and distillation there was obtained a fraction having b.p. 130°-7°/12 Torr (yield 77%) containing 90-95% of the desired allenic alcohol in the form of a diastereoisomeric mixture.

Provenance & Evidence