反应详情

温度

25 °C

To 19.5 g (0.1 M) of methyl N-carbethoxy-2-chloroglycinate and 17.0 g (0.1 M) of bis-trimethylsilyl acetylene in 200 ml of methylene chloride at 0° C is added 13.5 g (0.1 M) of aluminum chloride and the reaction mixture is allowed to warm to 25° C. After 24 hours at 25° C water is carefully added to the mixture which is then extracted with methylene chloride. The combined organic solutions are dried over magnesium sulfate, concentrated and distilled with the b.p. 100°/0.15 mm fraction collected to give methyl 2-trimethylsilylacetylene-2-carbethoxyaminoacetate.

1. extractionis then extracted with methylene chloride
2. dry with materialThe combined organic solutions are dried over magnesium sulfate
3. concentrationconcentrated
4. distillationdistilled with the b.p. 100°/0.15 mm fraction
5. customcollected