Potassium Carbonate → HCID 20352656, compound

Participants

Reaction Steps

12.4 g of 3-methyl-3-(3,4-ethylenedioxybenzyl)-piperazine (1a) are dissolved in 200 ml of dry acetone, combined with 20.7 g of potassium carbonate and 14.8 g of diphenylmethyl bromide, and heated for four hours with stirring under reflux. The inorganic salts are filtered off and the filtrate is evaporated to dryness is vacuum. The residue is taken up in 300 ml of diethyl ether and washed with water until the wash water no longer contains halogen. After drying with magnesium sulfate, hydrogen chloride is introduced into the organic phase. The precipitated hydrochloric is filtered off and washed with a little ether. Thereafter, it it suspended in a little water, combined with 20% ammonium hydroxide solution until alkaline, and extracted three times with 50 ml of diethyl ether. The organic phases are dried over magnesium sulfate and reduced to dryness. 19 g (91.6%) of 1-diphenylmethyl-3-methyl-3-(3,4-ethylenedioxybenzyl)-piperazine (3a) are obtained.

Provenance & Evidence