Methyl iodide → HCID 20352633, compound

Participants

Reaction Steps

15 g of 1-diphenylmethyl-3-methyl-3-(3,4-ethylenedioxybenzyl)-piperazine (3a) are dissolved in 200 ml of acetone, combined with 10 g of potassium carbonate, and heated to boiling with stirring. 5.6 g of methyl iodide in 50 ml of acetone are added dropwise in the course of two hours. After a further five hours at reflux with stirring, the mixture is filtered and the filtrate evaporated to dryness in vacuum. The residue is taken up in 200 ml of diethyl ether, washed free of halogen with water, dried over sodium sulfate, and the filtrate is evaporated to dryness is vacuum. 12.9 g (83%) of 1-diphenylmethyl-3-methyl-3-(3,4-ethylenedioxybenzyl)-4-methylpiperazine (4a) are obtained.

Provenance & Evidence