反应详情

This example illustrates the process of the invention wherein 1-(mono)-alkoxycarbonyl-S-methylisothiourea is used in place of a mixture of the mono- and bis-alkoxycarbonyl-reagents. In this example, a solution containing 2.1 g. of β-methylamino-β-phenylethylamine dihydrochloride, 1.64 g. of sodium acetate and 2.4 g. of 1-methoxycarbonyl-S-methylisothiourea in 20 ml. of 50%, wt., aqueous methanol is gently refluxed for two hours. The resulting heavy slurry is cooled, filtered and the collected solid product then washed with methanol affording 1-methyl-4,5-dihydro-5-phenyl-2-methoxycarbonylaminoimidazole.

1. temperatureThe resulting heavy slurry is cooled
2. filtrationfiltered
3. washthe collected solid product then washed with methanol