反应详情

A mixture of 6 g of 2-amino pyridine and 60 ml of anhydrous acetone was added to a mixture of 16 g of the product of Stage B and 20 ml of acetone at ambient temperature. The mixture was refluxed for one hour and the acetone was partially distilled. The mixture was allowed to return to ambient temperature, ice-cooled, separated and washed with ethyl ether. The insoluble part was dissolved in a saturated solution of sodium carbonate and extraction was carried out with ethyl acetate. The extracts were washed with water saturated in sodium chloride, dried and filtered to obtain 5.9 g of the expected product in the form of a yellow oil.

1. temperatureThe mixture was refluxed for one hour
2. distillationthe acetone was partially distilled
3. customto return to ambient temperature
4. temperatureice-cooled
5. customseparated
6. washwashed with ethyl ether
7. dissolutionThe insoluble part was dissolved in a saturated solution of sodium carbonate and extraction
8. washThe extracts were washed with water saturated in sodium chloride
9. customdried
10. filtrationfiltered