反应详情

温度

10 °C

A mixture of 3.5 g of the product of Stage C and 50 ml of chloroform was cooled to 10° C. and 4.55 g of N-bromo succinimide were added. The mixture was stirred at this temperature for 30 minutes and was then poured into a saturated solution of sodium carbonate and extracted with ethyl acetate. The extracts were washed with a saturated aqueous solution of sodium chloride, dried, filtered and evaporated to dryness to obtain after chromatography on silica (methylene chloride: 95/methanol: 5), 3.8 g of the expected product in the form of a black oil.

1. extractionextracted with ethyl acetate
2. washThe extracts were washed with a saturated aqueous solution of sodium chloride
3. customdried
4. filtrationfiltered
5. customevaporated to dryness