反应详情

A solution of diazomethane (60 mg.) in diethyl ether (10 ml.) was added to 7-[3,4-dihydroxy-2-(3-hydroxyoctyl)cyclopentyl]heptanoic acid (0.3 g.; prepared as described in Example 1(q)) and the reaction mixture was left to stand for one day at room temperature. The polymethylenes formed as by-products of the reaction were removed by filtration and the filtrate was washed with dilute aqueous sodium carbonate solution. Evaporation of the ethereal solution gave crude methyl 7-[3,4-dihydroxy-2-(3-hydroxyoctyl)cyclopentyl]heptanoate (0.26 g.), νmax 3450 cm-1, 1730 cm-1.

1. waitthe reaction mixture was left
2. customThe polymethylenes formed as by-products of the reaction
3. customwere removed by filtration
4. washthe filtrate was washed with dilute aqueous sodium carbonate solution
5. customEvaporation of the ethereal solution