反应详情

103 G. of 8-fluoro-2-methyl-dibenzo[b,f]thiepin-10(11H)-one are suspended in 550 ml. of ethanol and treated with 24.3 g. of sodium borohydride. The mixture is heated under reflux for about 10 minutes. After the addition of water, the mixture is extracted with chloroform. The organic phase is washed with water, dried over sodium sulfate and evaporated, and there is obtained racemic 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10ol as an oil.

1. temperatureThe mixture is heated
2. temperatureunder reflux for about 10 minutes
3. extractionthe mixture is extracted with chloroform
4. washThe organic phase is washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated