Hydrochloric Acid → 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin

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Reaction Steps

103 G. of racemic 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-ol, 500 ml. of benzene and 38.4 g. of finely powdered calcium chloride are saturated with hydrochloric acid gas at 15° C. and stirred overnight. The precipitate is removed by filtration, washed with benzene and evaporated under reduced pressure, and there is obtained racemic 10-chloro-8-fluoro-10,11-dihydro-2-methyl-dibenzo[ b,f]thiepin which melts at 63°-64° C.

Provenance & Evidence