反应详情

A mixture containing 100 g. of amyl nitrate and 600 ml. of bromoform is warmed to 70° C and then a total of 100 g. of 2-amino-5-methoxycarbonylthiazole is added portionwise with rapid stirring while maintaining the temperature at about 95°-100° C. The mixture is then stirred for an additional ten minutes at this temperature and then the bromoform is distilled off under vacuum. The residue is chromatographed on silica gel yielding 2-bromo-5-methoxycarbonylthiazole.

1. additionA mixture containing 100 g
2. temperaturewhile maintaining the temperature at about 95°-100° C
3. stirringThe mixture is then stirred for an additional ten minutes at this temperature
4. distillationthe bromoform is distilled off under vacuum
5. customThe residue is chromatographed on silica gel