Isopropylamine → 1-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

HRID 372188Notes

Reaction equation

HRID 372188 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[O:5]1[CH:7]([CH2:8][O:9][C:10]2[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=2)[CH2:6]1>C(O)C>[CH:1]([NH:4][CH2:6][CH:7]([OH:5])[CH2:8][O:9][C:10]1[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 20328376N-(4-Methylhexyl)-2-[(oxiran-2-yl)methoxy]-1,3-thiazole-5-carboxamide

Product 1

HCID 203285121-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example illustrates further methods according to the invention of preparing the compounds of formula I to the invention. In this example 0.6 g. of isopropylamine is added to a solution containing 0.3 g. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol, and then allowed to stand for 12 hours at room temperature. The mixture is then evaporated to dryness and the resulting residue chromatographed on silica gel yielding 1-isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol.

Workup

  1. customaccording to the invention of preparing the compounds of formula I to the invention
  2. additioncontaining 0.3 g
  3. customThe mixture is then evaporated to dryness
  4. customthe resulting residue chromatographed on silica gel

Sources & evidence

ORD record
ord-0ca81e2f873f4686b546d918eb56080f
Source dataset
uspto-grants-1978_05
Patent number
US04089865

Reaction notes

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